Dr. Younis Baqi
Sultan Qaboos University
Dr. Baqi is associate professor of Bio-organic Chemistry at Chemistry Department, College of Science, Sultan Qaboos University in Muscat, Oman. Dr. Baqi is a medicinal chemist with interests in the development of small molecules as selective ligands for purinergic receptors (G protein-coupled receptors), and ecto-nucleotidases inhibitors. This includes natural products isolation and synthesis of new organic compounds, including combinatorial approaches, and the analysis of structure-activity relationships.
Antithrombotic P2Y12 receptor antagonists: recent developments in drug discovery
The P2Y12 receptor is one of eight known P2Y receptor subtypes, and belongs to the G-protein-coupled receptor (GPCR) family. The P2Y12 receptor is highly expressed on blood platelets and in the brain. Potent, selective, peripherally acting antagonists for the P2Y12 receptor are used clinically as antithrombotic drugs. Several different scaffolds have been identified as P2Y12 receptor antagonists, including irreversibly acting thienotetrahydropyridines (prodrugs), and reversible competitive antagonists, including adenine nucleotide analogs, piperazinyl-glutamate-quinolines, -pyridines, and -pyrimidines, and anthraquinone derivatives. Here, we provide an overview of the different scaffolds that have been developed as P2Y12 receptor antagonists, some of which have become important therapeutics.